Finding the right antibiotic matters. When a single drug fails to clear a bacterial infection, doctors in India commonly prescribe Cefixime and Ofloxacin tablet brands in India for stronger, faster results. This powerful combination targets bacteria in two different ways at the same time. Cefixime breaks down the bacterial cell wall. Ofloxacin stops bacteria from reproducing. Together, they fight a wide range of infections more effectively than either drug alone.
These tablets treat some of the most common bacterial conditions. This includes urinary tract infections, respiratory infections, typhoid fever, and skin infections. India has many trusted pharmaceutical companies producing this combination under different brand names. Quality, pricing, and availability vary across brands. Knowing your options helps you and your doctor make a better, more informed treatment decision. This guide covers everything you need to know.
List of the Top Cefixime and Ofloxacin Tablets in India
Below is a detailed look at the best Cefixime and Ofloxacin tablet brands available in India, covering their composition, manufacturer credentials, and key clinical applications.
Frencef-O Tablet — By Frentis Healthcare
Composition: Cefixime + Ofloxacin
Frencef-O is manufactured by Frentis Healthcare, a trusted name in the Indian pharma industry known for producing quality pharmaceutical products across multiple therapeutic segments. This tablet is indicated for moderate to severe bacterial infections affecting the urinary tract, respiratory system, and gastrointestinal tract.
What sets Frencef-O apart is its adherence to strict quality control and safety protocols throughout the manufacturing process. Frentis Healthcare has built a strong reputation for offering clinically effective medicines at competitive prices, making Frencef-O a preferred option for both prescribers and pharma franchise partners across India.
- Best for: UTIs, respiratory infections, gastrointestinal infections
- Key strength: Dual-action formula with consistent quality assurance
Also Read: Top 10 Best Ofloxacin and Ornidazole Tablets Ip in India (2026) – Doctor-Recommended Brands
Mahacef-Plus Tablet — By Mankind Pharma
Composition: Cefixime 200 mg + Ofloxacin 200 mg
Mahacef-Plus is one of the most recognizable Cefixime and Ofloxacin tablets in India, manufactured by Mankind Pharma — an ISO-certified pharmaceutical giant with a massive pan-India distribution network. Each tablet delivers 200 mg of both Cefixime and Ofloxacin, making it a strong option for moderate-to-severe bacterial infections.
Doctors widely prescribe Mahacef-Plus for typhoid fever, UTIs, respiratory tract infections, and skin infections due to its proven clinical efficacy. Mankind Pharma’s robust manufacturing infrastructure and stringent quality benchmarks ensure that every batch of Mahacef-Plus meets the highest pharmaceutical standards.
| Parameter | Details |
| Strength | Cefixime 200 mg + Ofloxacin 200 mg |
| Manufacturer | Mankind Pharma |
| Certification | ISO-certified |
| Common Uses | UTIs, typhoid, respiratory, skin infections |
Zifi-O Tablet — By FDC Ltd
Composition: Cefixime 200 mg + Ofloxacin 200 mg
Zifi-O by FDC Ltd is a well-established and frequently prescribed antibiotic combination in Indian hospitals and clinics. It is indicated for bacterial infections of the skin, ears, lungs, prostate, and urinary tract, offering dual-action bactericidal coverage.
FDC Ltd is a reputed pharmaceutical company with decades of market presence in India. Their commitment to maintaining high-quality standards at every stage — from raw material sourcing to final packaging — makes Zifi-O one of the most trusted brands in this category. For patients seeking fast bacterial eradication and reliable results, Zifi-O is a strong prescription choice.
Factors to Consider Before Choosing the Best Cefixime and Ofloxacin Tablet Brand in India
With so many brands available, selecting the right one requires careful evaluation. Here are the most important factors to consider:
1. Manufacturer Reputation and Certifications Always choose a brand manufactured by a company certified by WHO-GMP, ISO, or other regulatory bodies. These certifications confirm that the production facility meets international quality and safety standards.
2. Drug Composition and Strength Most adult formulations contain 200 mg Cefixime + 200 mg Ofloxacin. However, some brands offer dispersible tablets with 100 mg + 100 mg for pediatric or elderly patients. Match the strength to the patient’s clinical need and doctor’s prescription.
3. Clinical Indication Match Different infections may require different treatment durations and doses. Confirm that the chosen brand is indicated for your specific infection — whether it is a UTI, respiratory infection, typhoid, or skin infection.
4. Availability and Distribution Network A brand with a strong pan-India distribution network ensures that refills are available consistently, especially in Tier-2 and Tier-3 cities.
5. Price and Affordability India has several affordable generic brands alongside premium ones. For pharma franchise purposes or patient access, compare pricing without compromising on quality.
6. Doctor’s Prescription This is the most important factor of all. Never self-medicate with antibiotics. Always follow the antibiotic prescribed by your doctor, including the complete course duration, to avoid antibiotic resistance.
Benefits of Cefixime and Ofloxacin Tablets for Treating Bacterial Infections
The Cefixime and Ofloxacin combination is clinically valued for several key reasons:
Dual Mechanism of Action Cefixime targets the bacterial cell wall, while Ofloxacin targets bacterial DNA replication. This two-pronged attack makes it significantly harder for bacteria to survive or develop resistance compared to single-drug therapy.
Broad-Spectrum Antibacterial Coverage The combination is effective against both gram-positive and gram-negative bacteria, covering a wide range of pathogens responsible for common infections in India.
Faster Symptom Relief Clinical use shows that patients typically begin experiencing relief within 24–48 hours for respiratory infections and within 3–5 days for urinary tract infections, making it one of the faster-acting oral antibiotic combinations.
Reduced Risk of Antibiotic Resistance Using two antibiotics with different targets simultaneously reduces the likelihood of bacteria developing resistance, which is increasingly critical in the era of antimicrobial resistance (AMR).
Convenient Oral Administration Available as standard tablets and dispersible tablets, this combination can be taken at home without the need for injections, improving patient compliance.
Suitable for Multiple Infection Types One formulation covers a wide range of clinical conditions — from bronchitis and sinusitis to typhoid fever and skin abscesses — making it a versatile choice for general practitioners.
Taxim OF Tablet — By Alkem Laboratories Ltd
Composition: Cefixime 200 mg + Ofloxacin 200 mg
Taxim OF is manufactured by Alkem Laboratories Ltd, one of India’s most research-oriented pharmaceutical companies. It is prescribed for moderate-to-severe bacterial infections where a broader spectrum of antibacterial action is needed.
When a single antibiotic is clinically insufficient, doctors often turn to Taxim OF for its reliable dual-action performance. Alkem’s strong emphasis on innovative pharmaceutical research and advanced manufacturing ensures that Taxim OF consistently delivers high therapeutic efficacy.
Omnix O Tablet — By Cipla Ltd
Composition: Cefixime 200 mg + Ofloxacin 200 mg
Manufactured by Cipla Ltd — one of India’s most globally recognized pharmaceutical companies — Omnix O is a premium-quality antibiotic combination used for infections of the lungs, urinary tract, digestive system, and skin.
Cipla’s commitment to quality, affordability, and innovation means that Omnix O is produced under stringent controls from raw material testing to final product packaging. The brand is widely trusted by healthcare providers across India and abroad.
Hifen Plus 200 mg/200 mg Tablet — By Hetero Drugs Ltd
Composition: Cefixime 200 mg + Ofloxacin 200 mg
Hifen Plus is manufactured by Hetero Drugs Ltd, a company known for its state-of-the-art manufacturing units and commitment to affordable, quality medicines. This tablet is indicated for bacterial infections of the urinary tract, reproductive tract, digestive system, and skin.
Hetero Drugs ensures that each batch of Hifen Plus passes rigorous quality checks, making it a dependable option for both prescribers and patients. Its affordability without compromise on quality makes it particularly valuable for wider patient access across India.
Milixim-O 100 mg/100 mg Tablet DT — By Glenmark Pharmaceuticals Ltd
Composition: Cefixime 100 mg + Ofloxacin 100 mg (Dispersible Tablet)
Milixim-O is a dispersible tablet (DT) — meaning it dissolves in water — making it the ideal formulation for children and elderly patients who have difficulty swallowing standard tablets. Manufactured by Glenmark Pharmaceuticals Ltd, a research-driven company known for patient-friendly innovations, Milixim-O treats mild-to-moderate bacterial infections with the same dual-action mechanism but at a lower dose.
| Feature | Details |
| Formulation | Dispersible Tablet (DT) |
| Strength | Cefixime 100 mg + Ofloxacin 100 mg |
| Best for | Children, elderly, patients with swallowing difficulty |
| Manufacturer | Glenmark Pharmaceuticals Ltd |
Cefolac-O 200 Tablet — By Macleods Pharmaceuticals Pvt Ltd
Composition: Cefixime 200 mg + Ofloxacin 200 mg
Cefolac-O 200 is manufactured by Macleods Pharmaceuticals Pvt Ltd, one of India’s fastest-growing pharmaceutical companies. With large-scale manufacturing capabilities and strict adherence to GMP (Good Manufacturing Practices) guidelines, Macleods ensures that Cefolac-O delivers consistent potency and safety.
This tablet is widely used for UTIs, respiratory infections, and gastrointestinal disorders, making it a go-to choice for physicians treating a diverse range of bacterial conditions.
Cefi O 200 Tablet — By Abbott
Composition: Cefixime 200 mg + Ofloxacin 200 mg
Cefi O 200 is a premium-quality antibiotic tablet from Abbott — a globally respected pharmaceutical company with a long-standing presence in India. Abbott’s substantial investment in research, innovation, and advanced manufacturing technology ensures that Cefi O 200 is produced at the highest purity and potency standards.
This brand is particularly recognized for its consistent performance and reliable therapeutic outcomes, making it a preferred choice for clinicians seeking a trustworthy antibiotic combination.
CO2 H Tablet DT — By Medley Pharmaceuticals
Composition: Cefixime 100 mg + Ofloxacin 100 mg (Dispersible Tablet)
CO2 H Tablet DT by Medley Pharmaceuticals is another dispersible tablet formulation designed for patients who prefer a lower dose or need an easier-to-administer form. Medley Pharmaceuticals is an ISO-certified company known for producing cost-effective, high-quality medicines accessible across India.
This tablet is especially useful for treating mild-to-moderate bacterial infections in patients for whom the standard 200 mg combination may not be appropriate.
Quick Comparison: Top Cefixime and Ofloxacin Tablet Brands in India
| Brand Name | Manufacturer | Strength | Key Feature |
| Frencef-O | Frentis Healthcare | 200+200 mg | Broad coverage, quality protocols |
| Mahacef-Plus | Mankind Pharma | 200+200 mg | ISO-certified, widely prescribed |
| Zifi-O | FDC Ltd | 200+200 mg | Strong market presence |
| Taxim OF | Alkem Laboratories | 200+200 mg | Research-driven formulation |
| Omnix O | Cipla Ltd | 200+200 mg | Globally trusted brand |
| Hifen Plus | Hetero Drugs Ltd | 200+200 mg | Affordable, quality-assured |
| Milixim-O | Glenmark Pharmaceuticals | 100+100 mg | Dispersible, pediatric-friendly |
| Cefolac-O 200 | Macleods Pharmaceuticals | 200+200 mg | GMP-certified, fast-growing |
| Cefi O 200 | Abbott | 200+200 mg | Premium quality, global brand |
| CO2 H Tablet DT | Medley Pharmaceuticals | 100+100 mg | Dispersible, ISO-certified |
FAQs
What types of infections does the Cefixime and Ofloxacin combination treat?
This combination treats a wide range of bacterial infections including UTIs, respiratory tract infections, typhoid fever, skin infections, gastrointestinal infections, and certain sexually transmitted infections caused by gram-positive and gram-negative bacteria.
Is the Cefixime and Ofloxacin combination safe to use?
Yes, it is safe when prescribed and taken as directed by a qualified doctor. Self-medication should always be avoided with antibiotics.
What is the usual dosage for adults?
The typical adult dose is one tablet (200 mg + 200 mg) twice daily after meals, for a duration of 5–7 days or as prescribed by the physician based on the type and severity of the infection.
Can children take Cefixime and Ofloxacin tablets?
Standard 200 mg tablets are generally not recommended for children without medical guidance. Dispersible tablet formulations with 100 mg + 100 mg, such as Milixim-O DT or CO2 H DT, may be used in pediatric cases under a doctor’s supervision.
Why is completing the full antibiotic course important?
Stopping antibiotics early, even when symptoms improve, can allow surviving bacteria to develop resistance. Completing the full prescribed course ensures complete bacterial eradication and reduces the risk of antibiotic-resistant infections.
Do all these manufacturers follow quality standards?
Yes, the brands listed above are manufactured by companies that adhere to regulatory guidelines such as WHO-GMP, ISO, and Schedule M requirements of India’s Central Drugs Standard Control Organisation (CDSCO).
Can Cefixime and Ofloxacin tablets be taken on an empty stomach?
It is generally recommended to take them after meals to minimize the risk of stomach upset or gastrointestinal side effects.
Are these tablets suitable for pharma franchise business opportunities?
Yes, many of these brands — including Frencef-O by Frentis Healthcare and others — are available for PCD pharma franchise and third-party manufacturing arrangements, making them viable options for pharma entrepreneurs.
Conclusion
The Cefixime and Ofloxacin tablet combination remains one of the most clinically effective dual antibiotic therapies available in India for managing a broad spectrum of bacterial infections. From globally recognized names like Cipla and Abbott to trusted domestic manufacturers like Mankind Pharma, Alkem Laboratories, and Hetero Drugs, the Indian pharmaceutical market offers high-quality options across various price points and formulation types.
Whether you are a healthcare professional looking for a reliable prescription option, a patient seeking clarity on your prescribed medicine, or a pharma entrepreneur exploring franchise opportunities, this guide covers the top brands that maintain the highest standards of safety, efficacy, and quality.
Always remember — antibiotics like Cefixime and Ofloxacin must only be taken under a doctor’s prescription, following the complete prescribed course, to ensure effective treatment and to help combat the growing challenge of antibiotic resistance in India.
